Methadone is a medication that a substitute for illegal drugs such as heroin that carry high risks for both the mother and baby. Detoxing from methadone is not recommended during the first trimester since the percentage of having a miscarriage is very high. Detoxing is not recommended in the last trimester because it may cause the mother to have withdrawal symptoms and make the mother stressed out and then that may cause the baby to have lack in oxygen. Babies exposed to methadone often suffer from low birth weight and height, small head circumference, and decreased fetal growth. Neonatal Opiate Abstinence Syndrome is a generalized disorder characterized by autonomic nervous system, gastrointestinal tract, and respiratory system dysfunctions, and central nervous system. Usually these symptoms first appear forty-eight to seventy-two hours after the birth, but may arrive later because methadone is stored in the fetal tissue.